Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2

Abstract

Five unusual macrolides, gliomasolides A–E (1–5), were isolated from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2. Their structures were established by extensive spectroscopic analyses and single-crystal X-ray diffraction studies. Structurally in common, these compounds feature a very rare 14-membered macrocyclic backbone lacking of methyl group. Cytotoxic effect of these metabolites against the growth of HeLa cell lines was evaluated, revealing that 1 exhibited moderate inhibitory effect with an IC₅₀ value of 10.1 μM.