Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 67, 2015
Previous Article Next Article

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

Author affiliations

Abstract

Novel nanofibrous materials composed of polyelectrolyte complexes (PECs) between N,N,N-trimethylchitosan iodide (TMCh) and poly(acrylic acid) (PAA) or poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) were prepared. This was achieved by facile one-pot electrospinning of solutions of the oppositely charged polyelectrolyte partners. It was rendered possible by using a solvent system containing formic acid and/or by adding a strongly ionized low-molecular-weight salt (CaCl2). Use of formic acid enabled TMCh/PAA nanofibers containing in situ synthesized silver nanoparticles (AgNPs) to be electrospun. The AgNPs had an average diameter of 3.0 ± 0.8 nm and were uniformly distributed in the nanofibers as evidenced by the performed transmission electron microscopic (TEM) analyses. The prepared nanofibers preserved their morphology and did not dissolve in phosphate-buffered saline (PBS). Hybrid AgNPs-containing PEC nanofibrous materials showed good antibacterial activity against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli and possessed higher efficacy than that of the nanofibers of the same composition without AgNPs and TMCh.

Graphical abstract: Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

Back to tab navigation

Supplementary files

Article information


Submitted
07 May 2015
Accepted
15 Jun 2015
First published
15 Jun 2015

RSC Adv., 2015,5, 54517-54526
Article type
Paper

Novel antibacterial electrospun materials based on polyelectrolyte complexes of a quaternized chitosan derivative

K. N. Kalinov, M. G. Ignatova, N. E. Manolova, N. D. Markova, D. B. Karashanova and I. B. Rashkov, RSC Adv., 2015, 5, 54517
DOI: 10.1039/C5RA08484A

Social activity

Search articles by author

Spotlight

Advertisements