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Issue 69, 2015
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Rapid and fast strategy for the determination of glutathione in the presence of vitamin B6 in biological and pharmaceutical samples using a nanostructure based electrochemical sensor

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Abstract

Cyclic voltammetry (CV), square wave voltammetry (SWV), electrochemical impedance spectroscopy (EIS) and double potential step chronoamperometry were used to investigate the electrochemical oxidation of glutathione (GSH) at a chemically modified electrode prepared by incorporating acetylferrocene (AF) and NiO nanoparticles (NiO/NPs) into a carbon paste matrix. For the mixture containing GSH and vitamin B6, the peak potentials were well separated from each other. Under optimal conditions in cyclic voltammetry, linear ranges spanned a GSH concentration from 0.2 μM to 350.0 μM and the detection limit was 0.09 μM at a signal-to-noise ratio of 3. The novel sensor was successfully used for the voltammetric determination of the GSH in real samples with satisfactory results.

Graphical abstract: Rapid and fast strategy for the determination of glutathione in the presence of vitamin B6 in biological and pharmaceutical samples using a nanostructure based electrochemical sensor

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Publication details

The article was received on 07 May 2015, accepted on 15 Jun 2015 and first published on 15 Jun 2015


Article type: Paper
DOI: 10.1039/C5RA08433D
RSC Adv., 2015,5, 56255-56261

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    Rapid and fast strategy for the determination of glutathione in the presence of vitamin B6 in biological and pharmaceutical samples using a nanostructure based electrochemical sensor

    M. Shabani-Nooshabadi and F. Tahernejad-Javazmi, RSC Adv., 2015, 5, 56255
    DOI: 10.1039/C5RA08433D

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