Issue 77, 2015

Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)2] terpolymers

Abstract

Nonlinear amphiphilic block copolymer architectures with precisely controlled structures bring new challenges to biomedical materials research. The paper describes the straightforward synthesis of new “snake tongue“ Y-shaped terpolymers containing poly(ethylene oxide) (PEO), poly(2-ethyl-2-oxazoline) (PEtOx) and poly(ε-caprolactone) (PCL) blocks into structure [AB(C)2] (herein referred to as [MPEO44-b-PEtOx252-b-(PCL)2×44], [MPEO44-b-PEtOx252-b-(PCL)2×87], [MPEO44-b-PEtOx252-b-(PCL)2×131]). A series of well-defined Y-shaped terpolymers were successfully synthesised by a combination of living cationic and anionic ring-opening polymerization (ROP). The selected Y-shaped [MPEO44-b-PEtOx252-b-(PCL)2×44] terpolymer self-assembly was characterised in detail by static and dynamic light scattering, nanoparticle tracking analysis and cryo-transmission electron microscopy. The physico-chemical properties as well as the molecular architecture effect on the self-assembled structures and on the LCST were compared with the Y-shaped [MPEO44-b-PEtOx252-b-(PCL)2×87] and the [MPEO44-b-PEtOx252-b-(PCL)2×131] terpolymers. The results indicated a temperature-induced aggregation with an LCST between 60–63 °C for the [MPEO44-b-PEtOx252-b-(PCL)2×44], at 60 °C for the [MPEO44-b-PEtOx252-b-(PCL)2×87] and between 45–50 °C for the [MPEO44-b-PEtOx252-b-(PCL)2×131] with significant differences in the supramolecular self-assembly behaviour compared with the analogous linear structure, clearly indicating the crucial effect of the molecular architecture. Furthermore, the increase of the molecular weight fraction of the hydrophobic block on the Y-shaped triblock terpolymers likely induced a decrease of the LCST.

Graphical abstract: Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)2] terpolymers

Supplementary files

Article information

Article type
Paper
Submitted
05 May 2015
Accepted
15 Jul 2015
First published
15 Jul 2015
This article is Open Access
Creative Commons BY license

RSC Adv., 2015,5, 62844-62854

Supramolecular self-assembly of novel thermo-responsive double-hydrophilic and hydrophobic Y-shaped [MPEO-b-PEtOx-b-(PCL)2] terpolymers

S. Petrova, C. G. Venturini, A. Jäger, E. Jäger, M. Hrubý, E. Pavlova and P. Štěpánek, RSC Adv., 2015, 5, 62844 DOI: 10.1039/C5RA08298F

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