Jump to main content
Jump to site search

Issue 62, 2015
Previous Article Next Article

A rapid metal free synthesis of 5-substituted-1H-tetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst

Author affiliations

Abstract

A convenient, rapid and metal free synthesis of 5-substituted-1H-tetrazoles is described by [3 + 2] cycloaddition reaction of nitriles with sodium azide. The reaction was catalyzed by cuttlebone in DMSO at 110 °C. Cycloaddition reaction of nitriles with sodium azide happened in the presence of mesoporous cuttlebone by “electrophilic activation” of nitriles through hydrogen bond formation between the cuttlebone and nitrile. Cuttlebone as a natural low cost heterogeneous catalyst with high porosity, high flexural stiffness, high compressive strength and high thermal stability affords 5-substituted-1H-tetrazoles rapidly with high efficiency.

Graphical abstract: A rapid metal free synthesis of 5-substituted-1H-tetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 May 2015, accepted on 29 May 2015 and first published on 29 May 2015


Article type: Paper
DOI: 10.1039/C5RA08147E
Author version
available:
Download author version (PDF)
Citation: RSC Adv., 2015,5, 49849-49860
  •   Request permissions

    A rapid metal free synthesis of 5-substituted-1H-tetrazoles using cuttlebone as a natural high effective and low cost heterogeneous catalyst

    S. S. E. Ghodsinia and B. Akhlaghinia, RSC Adv., 2015, 5, 49849
    DOI: 10.1039/C5RA08147E

Search articles by author

Spotlight

Advertisements