Issue 64, 2015
From the journal:

RSC Advances

Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides†

Xiao Guo,‡a   Jiaan Shao,‡a   Huan Liu,a   Binhui Chen,a   Wenteng Chena  and  Yongping Yu*a  

* Corresponding authors

a Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, 866 Yuhangtang Road, Zijin Campus, Hangzhou 310058, China
E-mail: yyu@zju.edu.cn

Abstract

A simple and direct synthesis of functionalized imidazoles from α-nitro-epoxides and amidines was developed. This reaction could proceed smoothly in a highly efficient and eco-friendly manner in moderate to excellent yields. A plausible mechanism has also been proposed.

Graphical abstract: Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides

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Article information

DOI
https://doi.org/10.1039/C5RA07770B
Article type
Communication
Submitted
28 Apr 2015
Accepted
02 Jun 2015
First published
02 Jun 2015

RSC Adv., 2015,5, 51559-51562

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Highly efficient and eco-friendly protocol to functionalized imidazoles via ring-opening of α-nitro epoxides

X. Guo, J. Shao, H. Liu, B. Chen, W. Chen and Y. Yu, RSC Adv., 2015, 5, 51559 DOI: 10.1039/C5RA07770B

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