Issue 65, 2015

Effect of a hierarchical hybrid micro/nanorough strontium-loaded surface on osseointegration in osteoporosis

Abstract

This study compared the effect of a hierarchical hybrid micro/nanorough titanium strontium-loaded (MNT-Sr) surface on osseointegration under osteoporotic conditions to those of implants with a smooth titanium surface (ST), microrough titanium surface (MT) etched with hydrofluoric acid (HF), and an NT-Sr surface obtained by magnetron sputtering. The MNT-Sr surface released Sr at a low rate over a long period. In vitro experiments showed that although the MT was the superior surface in terms of promoting bone marrow stromal cells (BMSCs) adhesion and proliferation, the MNT-Sr surface had better biocompatibility for BMSCs differentiation and induced more intercellular junctions than the other surfaces. After 12 weeks of implantation into the distal femurs of ovariectomized rats, MNT-Sr had the highest osseointegration, followed by MT, NT-Sr, and ST surfaces. These results suggest that MNT-Sr combines the advantages of hierarchical micro/nanotopography and Sr to enhance osseointegration in osteoporosis.

Graphical abstract: Effect of a hierarchical hybrid micro/nanorough strontium-loaded surface on osseointegration in osteoporosis

Article information

Article type
Paper
Submitted
19 Mar 2015
Accepted
28 May 2015
First published
29 May 2015

RSC Adv., 2015,5, 52296-52306

Author version available

Effect of a hierarchical hybrid micro/nanorough strontium-loaded surface on osseointegration in osteoporosis

Y. Li, Q. Fu, Y. Qi, M. Shen, Q. Niu, K. Hu and L. Kong, RSC Adv., 2015, 5, 52296 DOI: 10.1039/C5RA04914H

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