Octreotide acetate-templated self-assembly Pt nanoparticles and their anti-tumor efficacy

Abstract

Platinum nanoparticles (PtNPs) were assembled in a chain-like structure by activating chemical groups of the octreotide acetate (AOC) template. Tumor-bearing mice were inoculated with cervical carcinoma cells, and then treated with a low dose of AOC-PtNPs (AOC-PtNPs-L), a high dose of AOC-PtNPs (AOC-PtNPs-H), sterile physiological saline and cyclophosphamide. The results suggested that tumor inhibition rates of cyclophosphamide, AOC-PtNPs-L and AOC-PtNPs-H were 87.0%, 38.3% and 42.5%; and the apoptosis rates of the tumor-bearing mice were 30.95%, 23.41% and 26.64%, respectively. More importantly, the histopathological study results implied that AOC-PtNPs had no toxicity or side-effects on liver and kidney tissues, but obvious inhibitory effects on tumors. In addition, MTT assay results showed that the as-prepared AOC-PtNPs had a higher inhibition rate on Hela cells than that of AOC or PtNPs alone. Therefore, AOC-PtNPs have great potential as anti-tumor drugs for cancer therapy in the future.