Issue 34, 2015
From the journal:

RSC Advances

Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones†

Ping Qian,a   Yanling Dai,a   Haibo Mei,a   Vadim A. Soloshonok,cd   Jianlin Han*ab  and  Yi Pana  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: hanjl@nju.edu.cn
Fax: +86-25-83686133
Tel: +86-25-83686133

b High-Tech Research Institute of Nanjing University, Changzhou, China

c Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, 20018 San Sebastian, Spain

d IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain

Abstract

A new Ni-catalyzed asymmetric decarboxylative Mannich reaction between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoro-acetaldimine and β-keto-acids was developed, which was carried out at room temperature affording β-trifluoromethyl-β-amino ketones with excellent yields and diastereoselectivities.

Graphical abstract: Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones

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Article information

DOI
https://doi.org/10.1039/C5RA02653A
Article type
Communication
Submitted
11 Feb 2015
Accepted
09 Mar 2015
First published
09 Mar 2015

RSC Adv., 2015,5, 26811-26814

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Ni-catalyzed asymmetric decarboxylative Mannich reaction for the synthesis of β-trifluoromethyl-β-amino ketones

P. Qian, Y. Dai, H. Mei, V. A. Soloshonok, J. Han and Y. Pan, RSC Adv., 2015, 5, 26811 DOI: 10.1039/C5RA02653A

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