Issue 33, 2015

Metabolomic study of Chinese medicine Huang Qin decoction as an effective treatment for irinotecan-induced gastrointestinal toxicity

Abstract

The Huang Qin Decoction (HQD) has been used in China for over 1800 years for the treatment of gastrointestinal ailments. As a formulation derived from HQD, PHY906 shows an attenuation effect on chemotherapeutic-induced gastrointestinal toxicity. Method: to explore the mechanism of irinotecan (CPT-11)-induced gastrointestinal toxicity and the ameliorative effect of HQD, an integrated gas and liquid chromatography-mass spectrometry (GC/MS, LC/MS) approach was applied to detect serum metabolome changes in rats following a treatment of CPT-11 with/without HQD. Results: significant alterations in metabolic profiling were observed in CPT-11-treated groups versus control groups. HQD attenuated the side-effects with reversed glutamine, tryptophan and lipid metabolisms. Conclusion: this study demonstrated that HQD can effectively decrease CPT-11-induced side-effects, and the metabolism pathways involved were speculated to be novel targets for reducing CPT-11-induced gastrointestinal toxicity.

Graphical abstract: Metabolomic study of Chinese medicine Huang Qin decoction as an effective treatment for irinotecan-induced gastrointestinal toxicity

Supplementary files

Article information

Article type
Paper
Submitted
10 Feb 2015
Accepted
05 Mar 2015
First published
05 Mar 2015

RSC Adv., 2015,5, 26420-26429

Author version available

Metabolomic study of Chinese medicine Huang Qin decoction as an effective treatment for irinotecan-induced gastrointestinal toxicity

J. Wang, H. Fan, Y. Wang, X. Wang, P. Zhang, J. Chen, Y. Tian, W. Zhang, F. Xu and Z. Zhang, RSC Adv., 2015, 5, 26420 DOI: 10.1039/C5RA02581H

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