Issue 28, 2015

Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

Abstract

A simple and benign one-pot protocol for the synthesis of 2-amino selenopyridine derivatives 4 has been developed using ultrasound assisted multicomponent reactions of aldehydes, malononitrile and benzeneselenol in polyethylene glycol (PEG-400). Under similar reaction conditions, sterically hindered o,o′-disubstituted aromatic aldehydes provide the corresponding functionalized seleno dihydropyridines 5. In this process in total four new bonds (two C–C, one C–N and one C–Se) forms in one pot.

Graphical abstract: Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

Supplementary files

Article information

Article type
Communication
Submitted
07 Feb 2015
Accepted
19 Feb 2015
First published
19 Feb 2015

RSC Adv., 2015,5, 22168-22172

Author version available

Ultrasound assisted multicomponent reactions: a green method for the synthesis of highly functionalized selenopyridines using reusable polyethylene glycol as reaction medium

Md. N. Khan, S. Karamthulla, L. H. Choudhury and Md. S. Haque Faizi, RSC Adv., 2015, 5, 22168 DOI: 10.1039/C5RA02403J

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