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Issue 38, 2015
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Multilayer fluorescent magnetic nanoparticles with dual thermoresponsive and pH-sensitive polymeric nanolayers as anti-cancer drug carriers

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Abstract

A multi-step process was used to synthesize fluorescent folic acid (FA)-conjugated stimuli-responsive magnetic nanoparticles as anti-cancer drug nanocarriers. Sol–gel processing of tetraethyl orthosilicate and fluorescein isothiocyanate-conjugated 3-aminopropyltriethoxysilane was used to synthesize Fe3O4@SiO2–FITC followed by the distillation precipitation polymerization of 2-hydroxyethyl methacrylate and N,N′-methylenebis(acrylamide) to obtain Fe3O4@SiO2@P(HEMA) nanoparticles. Conjugating with FA and RAFT agent, Fe3O4@SiO2@P(HEMA)@P(NIPAAM-co-AA) nanoparticles were synthesized via the polymerization of N-isopropylacrylamide and acrylic acid. The core–shell structure of nanoparticles was revealed via TEM. Furthermore, the progression of each step was studied by means of FT-IR and TGA. VSM and XRD were used to show that the synthesized nanoparticles retain their superparamagnetic properties. The synthesized nanoparticles exhibited dual thermo- and pH-sensitive behaviours. These nanoparticles were used as nanocarriers of the anti-cancer drug doxorubicin via controlled release in simulated physiological and acidic conditions. In addition, the synthesized nanoparticles showed a relatively non-toxic nature to HeLa cells, whereas cell viability decreased significantly when cells were incubated with DOX-loaded nanoparticles.

Graphical abstract: Multilayer fluorescent magnetic nanoparticles with dual thermoresponsive and pH-sensitive polymeric nanolayers as anti-cancer drug carriers

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Publication details

The article was received on 24 Jan 2015, accepted on 12 Mar 2015 and first published on 12 Mar 2015


Article type: Paper
DOI: 10.1039/C5RA01444A
RSC Adv., 2015,5, 29653-29662

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    Multilayer fluorescent magnetic nanoparticles with dual thermoresponsive and pH-sensitive polymeric nanolayers as anti-cancer drug carriers

    M. Torkpur-Biglarianzadeh and M. Salami-Kalajahi, RSC Adv., 2015, 5, 29653
    DOI: 10.1039/C5RA01444A

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