Issue 29, 2015

Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

Abstract

A highly regioselective C–H/S–H cross-coupling of imidazo[1,2-a]pyridines with thiols has been developed using molecular oxygen to form the C-3 sulfenated products in the presence of a copper catalyst. It represents a simple process for the formation of C–S bonds to prepare thioether-decorated imidazo[1,2-a]pyridines. The reaction proceeds smoothly with a broad range of substrates to give imidazo[1,2-a]pyridines in good yields.

Graphical abstract: Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2015
Accepted
20 Feb 2015
First published
20 Feb 2015

RSC Adv., 2015,5, 22356-22360

Author version available

Regioselective copper-catalyzed thiolation of imidazo[1,2-a]pyridines: an efficient C–H functionalization strategy for C–S bond formation

H. Cao, L. Chen, J. Liu, H. Cai, H. Deng, G. Chen, C. Yan and Y. Chen, RSC Adv., 2015, 5, 22356 DOI: 10.1039/C5RA01342A

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