Issue 37, 2015

“On water” synthesis of highly functionalized 4H-chromenes via carbon–carbon bond formation under microwave irradiation and their antibacterial properties

Abstract

An ecofriendly and catalyst free synthesis of novel hybrid molecules of chromene and coumarin is described by C–C bond formation in an aqueous medium under microwave irradiation. The methodology provides cleaner conversion, a shorter reaction time and high regio selectivity which makes the protocol globally recognized. For the first time the reaction between a special type of allylic alcohols 2-hydroxy-2H-chromens and 4-hydroxy coumarin to produce novel functionalised 4H-chromenes in excellent yields was achieved and we evaluated their antibacterial properties.

Graphical abstract: “On water” synthesis of highly functionalized 4H-chromenes via carbon–carbon bond formation under microwave irradiation and their antibacterial properties

Supplementary files

Article information

Article type
Communication
Submitted
22 Jan 2015
Accepted
13 Mar 2015
First published
13 Mar 2015

RSC Adv., 2015,5, 28958-28964

“On water” synthesis of highly functionalized 4H-chromenes via carbon–carbon bond formation under microwave irradiation and their antibacterial properties

L. C. Rao, N. S. Kumar, V. Dileepkumar, U. S. N. Murthy and H. M. Meshram, RSC Adv., 2015, 5, 28958 DOI: 10.1039/C5RA01301A

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