Coupled electro-mechanic-chemical dynamics model for F1F0-motor

Abstract

F₁F₀-motor (ATP synthase) is a key link of the respiratory chain and its operation depends on the state and change of the respiratory chain. However, the relationship between these two has not yet been studied quantitatively. In this study, a coupled electro-mechanic-chemical dynamics model for the F₁F₀-motor was established. The power system (respiratory chain) and the control system were considered together, and the coupled electro-mechanic-chemical equations were proposed. The dynamic response of the motor to the main control parameters and nerve pulse was studied. Some experimental observations were simulated and discussed. The model offered complete insight about the operation of the F₁F₀-motor.