We developed a new efficient photolabile protecting group, 2-(2-nitrophenyl) propyl (Npp) that blocks the carboxyl group in peptide synthesis. The Npp group is quite compatible with the Fmoc–t-Bu strategy and can be removed rapidly and quantitatively by irradiation with UV light. Using this method, we prepared a head-to-tail cycloheptapeptide.
G. Wang, T. Peng, S. Zhang, J. Wang, X. Wen, H. Yan, L. Hu and L. Wang, RSC Adv., 2015, 5, 28344 DOI: 10.1039/C5RA01210D
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