Jump to main content
Jump to site search

Issue 33, 2015
Previous Article Next Article

Synthesis, characterization and biological properties of new hybrid carbosilane–viologen–phosphorus dendrimers

Author affiliations

Abstract

A series of hybrid carbosilane–viologen–phosphorus dendrimers was prepared, as a new example of the synthetic “onion peel” approach. This is based on a convergent strategy by combination of double alkylation of 4,4-bipyridine units with two different halogenated reagents, one of them as a carbosilane dendron, and their subsequent ligation to a hexafunctionalized phosphorus core through amine–aldehyde condensation reactions. In these systems two kinds of cationic groups were included: those located at the branches due to viologen quaternized units and those related to the ammonium groups at the surface of carbosilane wedges. This feature constitutes a novel situation to be explored in the search for new physical–chemical and biological properties, respecting traditional dendritic architectures. The biological properties of two of these hybrid molecules have been studied, focusing the investigation on their interactions with plasma proteins like human serum albumin (HSA), cytotoxicity and hemotoxicity experiments. Although the observed biological behaviors were mainly related to the presence of outer positive charges, in some cases the inner positive charges acted as fine tuning factors.

Graphical abstract: Synthesis, characterization and biological properties of new hybrid carbosilane–viologen–phosphorus dendrimers

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Jan 2015, accepted on 05 Mar 2015 and first published on 05 Mar 2015


Article type: Paper
DOI: 10.1039/C5RA00960J
Citation: RSC Adv., 2015,5, 25942-25958
  •   Request permissions

    Synthesis, characterization and biological properties of new hybrid carbosilane–viologen–phosphorus dendrimers

    S. Moreno, A. Szwed, N. El Brahmi, K. Milowska, J. Kurowska, E. Fuentes-Paniagua, E. Pedziwiatr-Werbicka, T. Gabryelak, N. Katir, F. Javier de la Mata, M. A. Muñoz-Fernández, R. Gomez-Ramirez, A. Caminade, J. Majoral and M. Bryszewska, RSC Adv., 2015, 5, 25942
    DOI: 10.1039/C5RA00960J

Search articles by author

Spotlight

Advertisements