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Issue 20, 2015
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Understanding the cation specific effects on the aqueous solubility of amino acids: from mono to polyvalent cations

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Abstract

The interactions established by mono and polyvalent cations in natural media have important implications on the structure formation, function and physico-chemical behavior of biomolecules, playing therefore a critical role in biochemical processes. In order to further elucidate the molecular phenomena behind the cation specific effects in biological environments, and clarify the influence of the charge of the ions, solubility measurements and molecular dynamics simulations were performed for aqueous solutions of three amino acids (alanine, valine and isoleucine), in the presence of a series of inorganic salts comprising mono-, di- and trivalent cations (LiCl, Li2SO4, K2SO4, CaCl2, AlCl3 and Al2(SO4)3). The evidence gathered indicates that the mechanism by which (salting-in inducing) polyvalent cations affect the solubility of amino acids in aqueous solutions is different from that of monovalent cations. A consistent and refined molecular description of the effect of the cation on the solubility of amino acids based on specific interactions of the cations with the negatively charged moieties of the biomolecules is here proposed.

Graphical abstract: Understanding the cation specific effects on the aqueous solubility of amino acids: from mono to polyvalent cations

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Publication details

The article was received on 09 Jan 2015, accepted on 23 Jan 2015 and first published on 02 Feb 2015


Article type: Paper
DOI: 10.1039/C5RA00501A
Citation: RSC Adv., 2015,5, 15024-15034
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    Understanding the cation specific effects on the aqueous solubility of amino acids: from mono to polyvalent cations

    L. I. N. Tomé, C. S. R. Sousa, J. R. B. Gomes, O. Ferreira, J. A. P. Coutinho and S. P. Pinho, RSC Adv., 2015, 5, 15024
    DOI: 10.1039/C5RA00501A

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