Issue 35, 2015
From the journal:

RSC Advances

Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore†

Xue Jiang,a   Meining Wang,b   Shanshan Song,c   Youjun Xu,*a   Zehong Miao*c  and  Ao Zhang*b  

* Corresponding authors

a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
E-mail: xuyoujun@syphu.edu.cn

b CAS Key Laboratory of Receptor Research, Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China
E-mail: aozhang@simm.ac.cn

c State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China
E-mail: zhmiao@simm.ac.cn

Abstract

A simple and more effective four-step synthesis of the tricyclic quinone–pyran–lactone skeleton was developed. Subsequent structural modification led to several series of derivatives. Regio- and diastereo-characteristics of these compounds were elucidated, and their antitumor activities against several cancer cells were investigated.

Graphical abstract: Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore

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Article information

DOI
https://doi.org/10.1039/C5RA00154D
Article type
Paper
Submitted
05 Jan 2015
Accepted
13 Mar 2015
First published
13 Mar 2015

RSC Adv., 2015,5, 27502-27508

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Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore

X. Jiang, M. Wang, S. Song, Y. Xu, Z. Miao and A. Zhang, RSC Adv., 2015, 5, 27502 DOI: 10.1039/C5RA00154D

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