Issue 19, 2015

Enantioselective first total synthesis of eujavanoic acid B through organocatalyzed IMDA reaction

Abstract

The first total synthesis of the polyketide eujavanoic acid B has been accomplished from an easily available and inexpensive starting material 1,3-propane diol. Maruoka asymmetric allylation, Julia olefination, HWE olefination and organocatalyzed intramolecular Diels–Alder reactions are the key steps involved in the present synthesis.

Graphical abstract: Enantioselective first total synthesis of eujavanoic acid B through organocatalyzed IMDA reaction

Supplementary files

Article information

Article type
Paper
Submitted
10 Dec 2014
Accepted
19 Jan 2015
First published
29 Jan 2015

RSC Adv., 2015,5, 14465-14469

Author version available

Enantioselective first total synthesis of eujavanoic acid B through organocatalyzed IMDA reaction

J. N. Kumar and B. Das, RSC Adv., 2015, 5, 14465 DOI: 10.1039/C4RA16136J

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