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Issue 26, 2015
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Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

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Abstract

We have developed a simple UV-visible spectrometric method for parallel detection of four drugs (venlafaxine, imipramine, amlodipine and alfuzosin) by using unmodified gold nanoparticles (Au NPs) as a colorimetric probe. The citrate was self-assembled onto the Au NPs to form a probe that undergoes a color change from red to blue by the addition of the four drugs. It is presumed that the color change is a result of the aggregation of the Au NPs induced by the four drugs, resulting a red-shift in their absorption spectra from 521 to 653, 695, 688 and 636 nm for venlafaxine, imipramine, amlodipine and alfuzosin, respectively. The method was validated in the concentration range of 0.001–100 μM, where it demonstrated good linearity (R2 = 0.997, 0.997, 0.995 and 0.998) with limits of detection in the range of 0.9–9.3 nM. The aggregation of the Au NPs induced by the four drugs was confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The applicability of the method was demonstrated by determining the drugs contents in pharmaceutical and biological samples (urine and plasma).

Graphical abstract: Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

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Supplementary files

Article information


Submitted
10 Dec 2014
Accepted
06 Feb 2015
First published
06 Feb 2015

RSC Adv., 2015,5, 19924-19932
Article type
Paper
Author version available

Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

K. A. Rawat, H. Basu, R. K. Singhal and S. K. Kailasa, RSC Adv., 2015, 5, 19924
DOI: 10.1039/C4RA16109B

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