Facile and diverse microwave-assisted synthesis of secondary propargylamines in water using CuCl/CuCl2

Tran Thi Thu Trang; Denis S. Ermolat'ev; Erik V. Van der Eycken

doi:10.1039/C4RA16005C

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Facile and diverse microwave-assisted synthesis of secondary propargylamines in water using CuCl/CuCl₂†

Tran Thi Thu Trang,^ab Denis S. Ermolat'ev^a and Erik V. Van der Eycken*^a

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* Corresponding authors

^a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium
E-mail: erik.vandereycken@chem.kuleuven.be
Fax: +32 16327990

^b Department of Chemistry, Hanoi National University of Education, Xuan Thuy 136, Hanoi, Vietnam

Abstract

A highly efficient microwave-assisted three-component reaction between an aldehyde, a primary amine and an alkyne was developed using an inexpensive Cu(I)/Cu(II) catalytic system and water as solvent. A wide range of diversely substituted secondary propargylamines was prepared in good and high yields within a short period of time.

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Article information

DOI: https://doi.org/10.1039/C4RA16005C
Article type: Paper
Submitted: 09 Dec 2014
Accepted: 17 Mar 2015
First published: 18 Mar 2015

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RSC Adv., 2015,5, 28921-28924

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Facile and diverse microwave-assisted synthesis of secondary propargylamines in water using CuCl/CuCl₂

T. T. T. Trang, D. S. Ermolat'ev and E. V. Van der Eycken, RSC Adv., 2015, 5, 28921 DOI: 10.1039/C4RA16005C

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