Facile syntheses of alkoxysilanated phosphorylcholines as surface modifiers: CuAAC and thiol-ene “click” reactions

Abstract

Eight alkoxysilanated phosphorylcholine (PC) compounds were synthesized from CuAAC (copper-catalyzed azide/alkyne cycloaddition) and thiol-ene “click” reactions. This methodology will provide simple and efficient routes for the synthesis of alkoxysilanated PC modifiers. To demonstrate modification ability of these products, they were implanted onto silica beads, and the loading rates were quantified.