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Issue 17, 2015
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Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels

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Abstract

A novel, micro-shock wave responsive spermidine and dextran sulfate microparticle was developed. Almost 90% of the drug release was observed when the particles were exposed to micro-shock waves 5 times. Micro-shock waves served two purposes; of releasing the antibiotic from the system and perhaps disrupting the S. aureus biofilm in the skin infection model. A combination of shock waves with ciprofloxacin loaded microparticles could completely cure the S. aureus infection lesion in a diabetic mouse model. As a proof of concept insulin release was triggered using micro-shock waves in diabetic mice to reduce the blood glucose level. Insulin release could be triggered for at least 3 days by exposing subcutaneously injected insulin loaded particles.

Graphical abstract: Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels

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Supplementary files

Article information


Submitted
26 Nov 2014
Accepted
16 Jan 2015
First published
16 Jan 2015

RSC Adv., 2015,5, 13234-13238
Article type
Paper
Author version available

Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels

D. P. Gnanadhas, M. Elango, M. B. Thomas, J. Gopalan and D. Chakravortty, RSC Adv., 2015, 5, 13234
DOI: 10.1039/C4RA15270K

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