Issue 16, 2015

Solid-state NMR studies of nucleic acid components


Recent applications of solid-state NMR to the characterisation of nucleic acid systems are reviewed. Developments in NMR methodology and DFT-based first-principles calculations have led to the emergence of “NMR crystallography”, where solid-state NMR provides information on local structure and dynamics that complements information on periodic ordering and overall structure provided by traditional diffraction crystallography. The solid-state NMR is shown to provide direct information on hydrogen-bonding arrangements, metal ion interactions and local molecular dynamics that is difficult to obtain by other techniques, including solution-state NMR.

Graphical abstract: Solid-state NMR studies of nucleic acid components

Article information

Article type
Review Article
12 Nov 2014
09 Jan 2015
First published
09 Jan 2015
This article is Open Access
Creative Commons BY license

RSC Adv., 2015,5, 12300-12310

Author version available

Solid-state NMR studies of nucleic acid components

M. Dračínský and P. Hodgkinson, RSC Adv., 2015, 5, 12300 DOI: 10.1039/C4RA14404J

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