Issue 12, 2015
From the journal:

RSC Advances

tert-Butyl hypochlorite mediated diastereoselective oxidative coupling: access to 1-functionalized tetrahydrocarbazoles†

Long Jiang,a   Xiaoni Xiea  and  Liansuo Zu*abc  

* Corresponding authors

a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084 China
E-mail: zuliansuo@biomed.tsinghua.edu.cn

b Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing, China

c Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China

Abstract

A mild and operationally simple protocol for the direct C–H functionalization of the 1-position of tetrahydrocarbazoles is reported. The diastereoselective oxidative coupling process is mediated by tert-butyl hypochlorite, and allows the successful generation of 1-functionalized tetrahydrocarbazoles with good to excellent yields and good functional group tolerance.

Graphical abstract: tert-Butyl hypochlorite mediated diastereoselective oxidative coupling: access to 1-functionalized tetrahydrocarbazoles

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Article information

DOI
https://doi.org/10.1039/C4RA14092C
Article type
Communication
Submitted
08 Nov 2014
Accepted
22 Dec 2014
First published
23 Dec 2014

RSC Adv., 2015,5, 9204-9207

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tert-Butyl hypochlorite mediated diastereoselective oxidative coupling: access to 1-functionalized tetrahydrocarbazoles

L. Jiang, X. Xie and L. Zu, RSC Adv., 2015, 5, 9204 DOI: 10.1039/C4RA14092C

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