Issue 11, 2015
From the journal:

RSC Advances

Anti-proliferative activity of the combination of salan Ti(iv) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: synergism with cisplatin†

Nitzan Ganot,a   Boris Redko,b   Gary Gellermanb  and  Edit Y. Tshuva*a  

* Corresponding authors

a The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
E-mail: edit.tshuva@mail.huji.ac.il
Fax: +972-2-6584282

b Department of Biological Chemistry, Ariel University of Samaria, Ariel 40700, Israel

Abstract

Two diaminobis(phenolato) Ti(IV) complexes were separately combined with azatoxin, camptothecin or cisplatin and underwent in vitro cytotoxicity analysis toward HT-29 and NCI-H1229 cancer cell lines. The methylated salan derivative exhibited synergistic effects with cisplatin at varying ratios toward both lines, when the compounds were administered fresh and simultaneously, implying great medicinal potential.

Graphical abstract: Anti-proliferative activity of the combination of salan Ti(iv) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: synergism with cisplatin

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Article information

DOI
https://doi.org/10.1039/C4RA13484B
Article type
Communication
Submitted
30 Oct 2014
Accepted
10 Dec 2014
First published
12 Dec 2014

RSC Adv., 2015,5, 7874-7879

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Anti-proliferative activity of the combination of salan Ti(IV) complexes with other organic and inorganic anticancer drugs against HT-29 and NCI-H1229 cells: synergism with cisplatin

N. Ganot, B. Redko, G. Gellerman and E. Y. Tshuva, RSC Adv., 2015, 5, 7874 DOI: 10.1039/C4RA13484B

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