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Issue 23, 2015
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Regulation and metabolic engineering of tanshinone biosynthesis

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Abstract

Salvia miltiorrhiza (Chinese name: dānshēn) is used in traditional Chinese medicine for the treatment of cardiovascular and cerebrovascular diseases. The tanshinones represent the most important biological active class of compounds present in dānshēn extracts. They are synthesized via either the cytoplasmic mevalonate or the plastidial 2-C-methyl-D-erythritol-4-phosphate pathway. Here, we summarize recent discoveries regarding the mechanisms underlying tanshinone biosynthesis and how the process is regulated. Tanshinone accumulation in planta is affected by a range of elicitors and by the composition of the culture medium. Its production in hairy root cultures can be enhanced by the over-expression of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, geranylgeranyl diphosphate synthase and allene oxide cyclase. The pathway leading to the biosynthesis of the tanshinone precursors miltiradiene and ferruginol, has been engineered in yeast.

Graphical abstract: Regulation and metabolic engineering of tanshinone biosynthesis

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Article information


Submitted
30 Oct 2014
Accepted
03 Feb 2015
First published
06 Feb 2015

RSC Adv., 2015,5, 18137-18144
Article type
Review Article
Author version available

Regulation and metabolic engineering of tanshinone biosynthesis

P. Ma, J. Liu, A. Osbourn, J. Dong and Z. Liang, RSC Adv., 2015, 5, 18137
DOI: 10.1039/C4RA13459A

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