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Issue 2, 2015
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Facile one-pot synthesis of 4-substituted semicarbazides

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A diverse library of twenty-five 4-mono- and disubstituted semicarbazides was prepared in a one-pot two-step approach. The method includes formation of a carbamate from bis(2,2,2-trifluoroethyl)carbonate or 2,2,2-trifluoroethylchloroformate and a primary or secondary amine and subsequent interaction of the carbamate with hydrazine to result in a semicarbazide. The approach allowed to obtain 4-substituted semicarbazides on a large scale in good yield and high purity.

Graphical abstract: Facile one-pot synthesis of 4-substituted semicarbazides

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The article was received on 15 Oct 2014, accepted on 24 Nov 2014 and first published on 02 Dec 2014

Article type: Paper
DOI: 10.1039/C4RA12425A
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Citation: RSC Adv., 2015,5, 1063-1069

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    Facile one-pot synthesis of 4-substituted semicarbazides

    A. V. Bogolubsky, Y. S. Moroz, P. K. Mykhailiuk, Y. V. Dmytriv, S. E. Pipko, L. N. Babichenko, A. I. Konovets and A. Tolmachev, RSC Adv., 2015, 5, 1063
    DOI: 10.1039/C4RA12425A

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