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Issue 20, 2015
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Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

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Abstract

Two organic radical contrast agents, TEMPO-Glc and TEEPO-Glc, were synthesized and their stabilities and contrast enhancing properties were tested with in vitro NMR and MRI experiments. Owing to the glucose moieties in the prepared compounds, this study presents potential candidates for a tumor targeting fully organic contrast agents for MRI.

Graphical abstract: Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

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Article information


Submitted
29 Sep 2014
Accepted
27 Jan 2015
First published
27 Jan 2015

RSC Adv., 2015,5, 15507-15510
Article type
Communication
Author version available

Synthesis and in vitro phantom NMR and MRI studies of fully organic free radicals, TEEPO-glucose and TEMPO-glucose, potential contrast agents for MRI

M. Soikkeli, K. Sievänen, J. Peltonen, T. Kaasalainen, M. Timonen, P. Heinonen, S. Rönkkö, V.-P. Lehto, J. S. Kavakka and S. Heikkinen, RSC Adv., 2015, 5, 15507
DOI: 10.1039/C4RA11455H

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