Issue 1, 2015

A highly efficient copper and ligand free protocol for the room temperature Sonogashira reaction

Abstract

A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira reaction of aryl iodides at room temperature. The system provides a simple route to obtain polyfunctional alkynes under ligand and copper free conditions. The procedure is equally efficient for aliphatic alkynes and aryl bromides.

Graphical abstract: A highly efficient copper and ligand free protocol for the room temperature Sonogashira reaction

Article information

Article type
Communication
Submitted
02 Sep 2014
Accepted
12 Nov 2014
First published
01 Dec 2014

RSC Adv., 2015,5, 16-19

Author version available

A highly efficient copper and ligand free protocol for the room temperature Sonogashira reaction

A. Gogoi, A. Dewan and U. Bora, RSC Adv., 2015, 5, 16 DOI: 10.1039/C4RA09630D

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