Facile synthesis and characterization of bio-organometallic compounds and their biological activity contour against human pathogens

Abstract

We have reported the synthesis of novel di & trisubstituted pyrroles and their biological activity. Most of the compounds show antibacterial activity towards gram positive and gram negative bacteria. The agar-diffusion method was used for prelude screening studies, which showed a hopeful broad range of antibacterial activity. The minimum inhibitory concentration (MIC) for bacteria was determined by the micro dilution method of selected active compounds. For the same compounds cytotoxicity assay was also performed. The photophysical properties were studied for the selected compounds and their results were suitably supported by DFT computation.