Synthesis and characterization of biocompatible tigecycline imbibed electrospun poly ε-caprolactone urethane urea fibers

Abstract

A novel antibiotic wound dressing for infected wounds was prepared by immersing electrospun poly ε-caprolactone urethane urea (PEUU) microfibers in tigecycline solution. The fibers were characterized using ATR-FTIR, ¹H NMR, TGA-DTA, DSC and XRD. In vitro release studies showed a burst followed by a sustained release of tigecycline. Bacterial inhibition tests confirmed that the sensitive tigecycline had its activity intact. The NIH 3T3 fibroblast cell attachment on microfibers was examined using DAPI fluorescence imaging and scanning electron microscopy. The present study confirmed the ease in preparation and the use of tigecycline loaded PEUU as promising antimicrobial scaffold for the treatment of skin and soft tissue infections. The significance and novelty of the work lies in the successful use of the scaffold as a bandage to prevent wound infections.