Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 62, 2015
Previous Article Next Article

Facile one-pot synthesis of different surfactant-functionalized water-soluble Fe3O4 nanoparticles as magnetic resonance imaging contrast agents for melanoma tumors

Author affiliations

Abstract

A facile and efficient solvothermal strategy is described to synthesize modified Fe3O4 nanoparticles (NPs) as magnetic resonance (MR) imaging contrast agents. In this study, glycerine was used not only as a solvent but also as a reducing agent due to its nontoxicity and high viscosity, which result in the advantages of good dispersibility and narrow size distribution of the Fe3O4 NPs. In addition, sodium citrate, L-asparagine and polyvinylpyrrolidone were employed as surfactants for the surface modification of Fe3O4 NPs on account of their non/low-toxicity, water-solubility and biocompatibility. The modification process was completed by one step rather than complicated grafting approaches. Moreover, the resultant aqueous solution of the modified Fe3O4 NPs turned out to be stable for more than 6 months with no flocculates or precipitates appearing in the stock fluids. Then, T2 weighted images and T2 relaxation times of the modified Fe3O4 NPs were examined to investigate their biological applications for magnetic resonance (MR) imaging as T2 contrast agents. As a consequence, the sodium citrate-modified Fe3O4 NPs exhibit a higher r2 relaxivity than that of sodium citrate combined with PVP and L-asparagine-modified Fe3O4 NPs. Furthermore, in order to investigate their contrast effect for melanoma tumors, we also carried out a study of in vitro cytotoxicity and an observation of the tissue sections. The results suggest that these modified Fe3O4 NPs may be potential contrast agents for detecting melanoma tumors.

Graphical abstract: Facile one-pot synthesis of different surfactant-functionalized water-soluble Fe3O4 nanoparticles as magnetic resonance imaging contrast agents for melanoma tumors

Back to tab navigation

Supplementary files

Article information


Submitted
16 Jun 2014
Accepted
12 May 2015
First published
12 May 2015

RSC Adv., 2015,5, 50557-50564
Article type
Paper

Facile one-pot synthesis of different surfactant-functionalized water-soluble Fe3O4 nanoparticles as magnetic resonance imaging contrast agents for melanoma tumors

L. Wu, C. Yang, Z. Lv, F. Cui, L. Zhao and P. Yang, RSC Adv., 2015, 5, 50557
DOI: 10.1039/C4RA05786D

Social activity

Search articles by author

Spotlight

Advertisements