2′-Cyanoethyl thioglycosides: effective nucleophiles for synthesis of (hetero)aryl thioglycosides under the catalysis of Cu

Abstract

2′-Cyanoethyl thioglycosides are designed and synthesized, which are demonstrated to function as powerful nucleophiles to a wide variety of organic iodides. The coupling reactions smoothly proceed under the catalysis of Cu to afford the corresponding (hetero)aryl thioglycosides in good to excellent yields.