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Issue 7, 2015
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Transition-metal free oxidative aliphatic C–H fluorination

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Abstract

A practical and highly selective fluorination of unactivated aliphatic C–H bonds without the use of transition metals has been developed. This C–H fluorination protocol is robust, operationally simple, scalable and compatible with moisture and air. Furthermore, the method exhibits a broad substrate scope and is applicable to late-stage fluorination of natural products and derivatives, which make it a valuable method for the synthesis of fluorinated complex molecules.

Graphical abstract: Transition-metal free oxidative aliphatic C–H fluorination

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Publication details

The article was received on 25 Mar 2015, accepted on 15 Apr 2015 and first published on 16 Apr 2015


Article type: Research Article
DOI: 10.1039/C5QO00095E
Citation: Org. Chem. Front., 2015,2, 806-810
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    Transition-metal free oxidative aliphatic C–H fluorination

    X. Zhang, S. Guo and P. Tang, Org. Chem. Front., 2015, 2, 806
    DOI: 10.1039/C5QO00095E

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