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Issue 3, 2015
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Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

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Abstract

1,2,3,4-Tetrahydroisoquinoline is one of the most important “privileged scaffolds” present in natural products. C1-chiral tetrahydroisoquinolines have exhibited a wide variety of bioactivities and found applications as chiral scaffolds in asymmetric catalysis. This paper summarizes novel catalytic stereoselective strategies that emerged in the last ten years for synthesis of 1,2,3,4-tetrahydroisoquinoline and 3,4-dihydroisoquinoline scaffolds, beyond the traditional Pictet–Spengler and related protocols, as well as their applications in the total synthesis of alkaloid natural products.

Graphical abstract: Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

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Publication details

The article was received on 08 Nov 2014, accepted on 14 Dec 2014 and first published on 16 Dec 2014


Article type: Review Article
DOI: 10.1039/C4QO00294F
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Org. Chem. Front., 2015,2, 288-299

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    Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

    W. Liu, S. Liu, R. Jin, H. Guo and J. Zhao, Org. Chem. Front., 2015, 2, 288
    DOI: 10.1039/C4QO00294F

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