Issue 1, 2015

Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation

Abstract

Selective modifications of life's basic components, such as polypeptides, are of great importance in both chemistry and biology. Herein, we have developed an unprecedented intramolecular amidation of the phenylalanine moiety in dipeptides via Pd-catalyzed sp2 C–H activation and C–N formation.

Graphical abstract: Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation

Supplementary files

Article information

Article type
Research Article
Submitted
30 Oct 2014
Accepted
27 Nov 2014
First published
28 Nov 2014

Org. Chem. Front., 2015,2, 51-54

Author version available

Direct amidation of the phenylalanine moiety in short peptides via Pd-catalyzed C–H activation/C–N formation

M. Yang, X. Jiang and Z. Shi, Org. Chem. Front., 2015, 2, 51 DOI: 10.1039/C4QO00282B

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