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Issue 37, 2015
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Supramolecular glycopolymers with thermo-responsive self-assembly and lectin binding

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Abstract

Incorporating monomers into sequence-defined synthetic macromolecules endows them to mimic nature which results in key residues being anchored in the molecular recognition pattern. Developing controlled carbohydrate sequences has critical importance in understanding the multivalent binding motifs of oligosaccharide and sequence-controlled glycopolymers to various lectins. Here, we describe the development of thermo-responsive copolymer scaffolds bearing adamantane groups that enable the formation of an inclusion complex with mono and hepta mannosylated-cyclodextrin molecules through host–guest interaction. We have demonstrated the synthesis of a triblock copolymer via RAFT polymerization, the complexation of the adamantane containing a thermoresponsive copolymer and α-D-mannose-CD, as well as their interactions with Con A.

Graphical abstract: Supramolecular glycopolymers with thermo-responsive self-assembly and lectin binding

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Supplementary files

Article information


Submitted
18 Jun 2015
Accepted
29 Jul 2015
First published
31 Jul 2015

Polym. Chem., 2015,6, 6623-6631
Article type
Communication
Author version available

Supramolecular glycopolymers with thermo-responsive self-assembly and lectin binding

N. Cakir, G. Hizal and C. R. Becer, Polym. Chem., 2015, 6, 6623 DOI: 10.1039/C5PY00939A

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