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Issue 2, 2015
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Polymer grafted recyclable magnetic nanoparticles

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This work reports on a new combination of recyclable magnetic nanoparticles, polymers and antibiotics that show increased effectiveness in combating bacterial infections. The direct-coprecipitation of iron salts strategy was used to generate superparamagnetic nanoparticles with a saturation magnetization of 59.5 emu g−1. A silica coating was applied and used to stabilize the magnetic nanoparticles and create a convenient platform for further functionalization. A variety of PMAA brushes with different lengths and densities were prepared on the magnetic nanoparticles with an average diameter size as small as 10 nm via surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization of methacrylic acid. The polymer grafted magnetic nanoparticles were removed from water solutions after antimicrobial testing using a magnet, thereby avoiding nano-based pollution of the environment. The bioactivity of an antibiotic (penicillin-G) over bacteria (Staphylococcus aureus and Escherichia coli) was significantly enhanced when physically bound to the PMAA grafted magnetic nanoparticles. The inhibition activity of the penicillin-nanoparticle complex was retained using recycled magnetic nanoparticles that had been reloaded with penicillin-G.

Graphical abstract: Polymer grafted recyclable magnetic nanoparticles

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Article information

17 Aug 2014
22 Sep 2014
First published
22 Sep 2014

Polym. Chem., 2015,6, 248-255
Article type

Polymer grafted recyclable magnetic nanoparticles

L. Wang, M. Cole, J. Li, Y. Zheng, Y. P. Chen, K. P. Miller, A. W. Decho and B. C. Benicewicz, Polym. Chem., 2015, 6, 248
DOI: 10.1039/C4PY01134A

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