Jump to main content
Jump to site search

Issue 45, 2015
Previous Article Next Article

Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-L-glutamate)-glycosylated dendron hybrids

Author affiliations

Abstract

Nano-assemblies prepared from glycosylated macromolecules are promising systems for modulating or mimicking the interactions between natural carbohydrates and their receptors. In the current work, polyester dendrons bearing focal point alkynes and peripheral C-linked α-galactose moieties were synthesized and coupled to helical poly(γ-benzyl-L-glutamate) (PBLG) to afford synthetic linear-dendritic glycopolypeptides. Both the dendrimer generation and the length of the PBLG were varied to provide a small library of amphiphiles with hydrophilic mass fractions ranging from 0.07 to 0.54. The self-assembly of the copolymers in water using a solvent exchange method was optimized and studied in detail. While the linear-dendritic copolymers composed of lower generation dendrons tended to aggregate, a copolymer composed of a 4th generation galactose-functionalized dendron and PBLG with a degree of polymerization of 28 formed micellar nano-assemblies whose size could be tuned by varying the self-assembly process. Overall, this study provides new insights into the effects of polymer architecture on self-assembly properties, while at the same time introducing a new platform for the preparation of bioactive nanoparticles.

Graphical abstract: Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jul 2015, accepted on 20 Sep 2015 and first published on 22 Sep 2015


Article type: Paper
DOI: 10.1039/C5PY01060H
Author version
available:
Download author version (PDF)
Citation: Polym. Chem., 2015,6, 7902-7912
  •   Request permissions

    Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-L-glutamate)-glycosylated dendron hybrids

    A. Peyret, J. F. Trant, C. V. Bonduelle, K. Ferji, N. Jain, S. Lecommandoux and E. R. Gillies, Polym. Chem., 2015, 6, 7902
    DOI: 10.1039/C5PY01060H

Search articles by author

Spotlight

Advertisements