Jump to main content
Jump to site search

Issue 31, 2015
Previous Article Next Article

Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

Author affiliations

Abstract

Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.

Graphical abstract: Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 May 2015, accepted on 22 Jun 2015 and first published on 02 Jul 2015


Article type: Communication
DOI: 10.1039/C5PY00750J
Author version
available:
Download author version (PDF)
Polym. Chem., 2015,6, 5565-5574
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

    P. M. Kharkar, K. L. Kiick and A. M. Kloxin, Polym. Chem., 2015, 6, 5565
    DOI: 10.1039/C5PY00750J

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements