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Issue 31, 2015
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Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

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Abstract

Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.

Graphical abstract: Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

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Supplementary files

Article information


Submitted
20 May 2015
Accepted
22 Jun 2015
First published
02 Jul 2015

This article is Open Access

Polym. Chem., 2015,6, 5565-5574
Article type
Communication
Author version available

Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

P. M. Kharkar, K. L. Kiick and A. M. Kloxin, Polym. Chem., 2015, 6, 5565
DOI: 10.1039/C5PY00750J

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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