Issue 31, 2015

Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

Abstract

Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.

Graphical abstract: Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2015
Accepted
22 Jun 2015
First published
02 Jul 2015
This article is Open Access
Creative Commons BY-NC license

Polym. Chem., 2015,6, 5565-5574

Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

P. M. Kharkar, K. L. Kiick and A. M. Kloxin, Polym. Chem., 2015, 6, 5565 DOI: 10.1039/C5PY00750J

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