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Issue 13, 2015
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A series of new supramolecular polycations for effective gene transfection

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Abstract

The development of safe and effective supramolecular polycations has attracted much attention. In this work, a series of novel cyclodextrin (CD)-based supramolecular assemblies were readily prepared via the host–guest interaction by assembling different adamantane-functionalized α-CD derivatives with multiple β-CD-cored polycations. The supramolecular assemblies were investigated in terms of their pDNA-binding capabilities, cytotoxicities, cellular internalization and gene transfection efficiencies in HEK293, HepG2 and C6 cell lines. The supramolecular polycations displayed low cytotoxicities, similar to those of the CD-cored carriers. After self-assemblies, the gene transfection efficiencies and antitumor abilities of the supramolecular carriers were significantly enhanced. The present study demonstrates that such supramolecular preparation of CD-based polycations could provide a flexible strategy for the design and development of new assemblies with high efficiency and low cytotoxicity.

Graphical abstract: A series of new supramolecular polycations for effective gene transfection

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Supplementary files

Article information


Submitted
18 Dec 2014
Accepted
28 Jan 2015
First published
30 Jan 2015

Polym. Chem., 2015,6, 2466-2477
Article type
Paper

A series of new supramolecular polycations for effective gene transfection

H. Hu, H. Song, B. Yu, Q. Cai, Y. Zhu and F. Xu, Polym. Chem., 2015, 6, 2466
DOI: 10.1039/C4PY01756K

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