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Issue 10, 2015
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Two-photon uncageable enzyme inhibitors bearing targeting vectors

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Abstract

The activity of two cyclooxygenase-2 enzyme inhibitors, Celecoxib and Lumiracoxib, could be suppressed by coupling to photo-labile protecting groups, so-called photocages. These groups could be further functionalized with a peptide targeting vector for specific cellular delivery. The enzyme inhibition potential of the cyclooxygenase-2 inhibitors could be regained upon two-photon excitation with tissue-transparent near-IR light at 800 nm.

Graphical abstract: Two-photon uncageable enzyme inhibitors bearing targeting vectors

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Publication details

The article was received on 17 Jun 2015, accepted on 16 Aug 2015 and first published on 20 Aug 2015


Article type: Communication
DOI: 10.1039/C5PP00245A
Citation: Photochem. Photobiol. Sci., 2015,14, 1821-1825
  • Open access: Creative Commons BY license
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    Two-photon uncageable enzyme inhibitors bearing targeting vectors

    P. Anstaett, V. Pierroz, S. Ferrari and G. Gasser, Photochem. Photobiol. Sci., 2015, 14, 1821
    DOI: 10.1039/C5PP00245A

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