Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 10, 2015
Previous Article Next Article

Photodynamic therapy (PDT) of cancer: from local to systemic treatment

Author affiliations


Photodynamic therapy (PDT) requires a medical device, a photosensitizing drug and adequate use of both to trigger biological mechanisms that can rapidly destroy the primary tumour and provide long-lasting protection against metastasis. We present a multidisciplinary view of the issues raised by the development of PDT. We show how spectroscopy, photophysics, photochemistry and pharmacokinetics of photosensitizers determine the mechanism of cell death and clinical protocols. Various examples of combinations with chemotherapies and immunotherapies illustrate the opportunities to potentiate the outcome of PDT. Particular emphasis is given to the mechanisms that can be exploited to establish PDT as a systemic treatment of solid tumours and metastatic disease.

Graphical abstract: Photodynamic therapy (PDT) of cancer: from local to systemic treatment

Back to tab navigation

Publication details

The article was received on 31 Mar 2015, accepted on 06 Jul 2015 and first published on 10 Jul 2015

Article type: Perspective
DOI: 10.1039/C5PP00132C
Author version
Download author version (PDF)
Photochem. Photobiol. Sci., 2015,14, 1765-1780

  •   Request permissions

    Photodynamic therapy (PDT) of cancer: from local to systemic treatment

    J. M. Dąbrowski and L. G. Arnaut, Photochem. Photobiol. Sci., 2015, 14, 1765
    DOI: 10.1039/C5PP00132C

Search articles by author