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Issue 7, 2015
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Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

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Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide–alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction.

Graphical abstract: Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

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Publication details

The article was received on 25 Nov 2014, accepted on 16 Dec 2014 and first published on 24 Dec 2014


Article type: Communication
DOI: 10.1039/C4OB02479F
Org. Biomol. Chem., 2015,13, 1974-1978

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    Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

    R. M. Moorman, M. B. Collier, B. H. Frohock, M. D. Womble and J. M. Chalker, Org. Biomol. Chem., 2015, 13, 1974
    DOI: 10.1039/C4OB02479F

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