This website uses cookies to give you the best user experience. If you continue without changing your settings we'll assume you are happy to receive all RSC cookies. You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions are also obtainable from the privacy link at the bottom of any RSC page.
Lite Version|Standard version
Home > Organic & Biomolecular ... >
Download
PDF
Rich HTML
Abstract | Cited by

Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin.

Graphical abstract: Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase

Page: ^ Top


Enter Keywords, author, title,reference, or DOI
Log in | Register