Issue 45, 2015
From the journal:

Organic & Biomolecular Chemistry

Rhodium(iii)-catalyzed annulation of arenes with alkynes assisted by an internal oxidizing N–O bond†

Zisong Qi,a   Guo-Dong Tang,ab   Cheng-Ling Pan*b  and  Xingwei Li*a  

* Corresponding authors

a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: xwli@dicp.ac.cn

b Laboratory of Multiscale Materials and Molecular Catalysis, School of Materials Science and Engineering, Anhui University of Science and Technology, Huainan 232001, China
E-mail: clpan@aust.edu.cn

Abstract

Rh(III)-catalyzed C–H activation of 3-aryl-dihydroisoxazoles in the coupling with diarylacetylenes has been developed under redox-neutral conditions. This reaction occurred under mild conditions with no by-product, and the N–O bond functions as an oxidizing directing group, leading to efficient synthesis of isoquinolines functionalized with a proximal secondary alcohol.

Graphical abstract: Rhodium(iii)-catalyzed annulation of arenes with alkynes assisted by an internal oxidizing N–O bond

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Article information

DOI
https://doi.org/10.1039/C5OB01886B
Article type
Communication
Submitted
11 Sep 2015
Accepted
08 Oct 2015
First published
13 Oct 2015

Org. Biomol. Chem., 2015,13, 10977-10980

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Rhodium(III)-catalyzed annulation of arenes with alkynes assisted by an internal oxidizing N–O bond

Z. Qi, G. Tang, C. Pan and X. Li, Org. Biomol. Chem., 2015, 13, 10977 DOI: 10.1039/C5OB01886B

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