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Issue 37, 2015
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Helical peptaibol mimics are better ionophores when racemic than when enantiopure

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Abstract

Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.

Graphical abstract: Helical peptaibol mimics are better ionophores when racemic than when enantiopure

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Publication details

The article was received on 06 Aug 2015, accepted on 21 Aug 2015 and first published on 21 Aug 2015


Article type: Communication
DOI: 10.1039/C5OB01652E
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Citation: Org. Biomol. Chem., 2015,13, 9580-9584
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    Helical peptaibol mimics are better ionophores when racemic than when enantiopure

    S. J. Pike, J. E. Jones, J. Raftery, J. Clayden and S. J. Webb, Org. Biomol. Chem., 2015, 13, 9580
    DOI: 10.1039/C5OB01652E

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