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Issue 47, 2015
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Copper-catalyzed arylation of biguanide derivatives via C–N cross-coupling reactions

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Abstract

An efficient copper-catalyzed cross-coupling reaction of biguanide hydrochloride derivatives with both aryl iodides and bromides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl halides containing functionalities such as nitriles, sulfonamides, ethers, and halogens. Alkyl and cyclic substituted biguanidines were also well tolerated.

Graphical abstract: Copper-catalyzed arylation of biguanide derivatives via C–N cross-coupling reactions

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The article was received on 19 Jun 2015, accepted on 25 Sep 2015 and first published on 25 Sep 2015


Article type: Paper
DOI: 10.1039/C5OB01258A
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Org. Biomol. Chem., 2015,13, 11432-11437

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    Copper-catalyzed arylation of biguanide derivatives via C–N cross-coupling reactions

    C. Zhang, B. Huang, A. Bao, X. Li, S. Guo, J. Zhang, J. Xu, R. Zhang and D. Cui, Org. Biomol. Chem., 2015, 13, 11432
    DOI: 10.1039/C5OB01258A

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